AUG 18, 2026 · JOURNAL ARTICLE
Adrenal androgen mediates the association between obesity and accelerated skeletal maturation in children and adolescents
Frontiers in Endocrinology
A well-designed retrospective cohort study with adequate sample size demonstrating a plausible mechanistic pathway (DHEA-S mediation) between obesity and advanced bone age, but limited by single-center design, cross-sectional analysis, and surrogate endpoint (bone age ratio rather than clinical outcomes).
Reported
Sample size1252
Age range4–12 years
Advanced maturation thresholdBA/CA ≥1.1