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Sophia Yu

Vanderbilt University Medical Center

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AUG 7, 2026 · JOURNAL ARTICLE

Mapping the hepatic regulatory landscape of estradiol in gonadectomized obese female and male mice at single-nucleus resolution

Biology of Sex Differences

Single-nucleus transcriptomics study mapping gene expression and regulatory networks in obese mice; mechanistic and exploratory, without clinical outcomes or direct human validation of therapeutic efficacy.

Hypothesis-GeneratingIn Sook Ahn Sophia Yu Yutian Zhao

Study details

DesignSingle-nucleus RNA sequencing study

InterventionChronic estradiol (E2) treatment

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