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Researcher

Ziyi Li

Shanghai East Hospital

1 development in the corpus

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AUG 9, 2026 · JOURNAL ARTICLE

Targeting Mitochondrial Complex I Protects Against Palmitic Acid–Induced Endothelial Dysfunction

Diabetes Obesity and Metabolism

Mechanistic proof-of-concept study in cell culture and rodent models identifying a pathway but lacking human efficacy or safety data needed to guide clinical practice.

Hypothesis-GeneratingRuoxuan Li Ziyi Li Chenxia Zhou

Study details

DesignExperimental mechanistic study: in vitro ce…

InterventionRotenone (Complex I inhibitor) or NDUFS4-ta…

ComparatorPalmitic acid–treated cells without interve…

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