AUG 14, 2026 · JOURNAL ARTICLE
Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone
npj Precision Oncology
A sound translational study using ex vivo patient tumors and Phase 1 clinical data to identify immune contexture—not antigen density—as a predictor of TCB response; clinically relevant but exploratory and not yet definitive for practice change.
Reported
IFNγ coefficient of variation135%
IFNγ coefficient of variation in…190%
IFNγ coefficient of variation in…52%