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Lorenzo Lucantonio

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

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MAY 16, 2026 · JOURNAL ARTICLE

An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.

Oncoimmunology

Preclinical organoid-based mouse model study demonstrating proof-of-concept for CD8+ T cell dysfunction characterization and ICI responsiveness, lacking direct clinical validation or comparative efficacy trials.

PreliminaryGiovanna Peruzzi Francesca Sozio Lorenzo Lucantonio

Study details

DesignPreclinical syngeneic orthotopic organoid t…

InterventionAnti-PD-1 treatment and CD8+ T cell depleti…

ComparatorSubcutaneous AKPS implants; untreated ortho…

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