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Anne-Cécile Soufflet

Centre hospitalier universitaire de Québec

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AUG 18, 2026 · JOURNAL ARTICLE

Modeling KRAS mutations in KMT2A::MLLT3 acute myeloid leukemia promotes leukemic progression and transcriptional rewiring

Leukemia

A mechanistic preclinical model study with supporting clinical cohort data showing KRAS mutations accelerate KMT2A::MLLT3 AML progression; limited by in vivo mouse model design and observational patient data without controlled comparison.

PromisingEva Bresson Martha María Juárez-Rodríguez Cancer Genomics and Diagnostics

Reported

Latency acceleration fold-change2.16 ± 0.65-fold

LSC frequency p-value0.0069

LSC frequency fold-increase>20-fold

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