AUG 14, 2026 · JOURNAL ARTICLE
Focused Update to International Consensus Recommendations for the Use of Prolonged‐Infusion Beta‐Lactam Antibiotics Among Severely Ill Adult Patients: Endorsed by the American College of Clinical Pharmacy, British Society for Antimicrobial Chemotherapy, Cystic Fibrosis Foundation, European Society of Clinical Microbiology and Infectious Diseases, Infectious Diseases Society of America, Society of Critical Care Medicine, and Society of Infectious Diseases Pharmacists
Pharmacotherapy the Journal of Human Pharmacology and Drug Therapy
Systematic review and meta-analysis of 28 RCTs with moderate certainty of evidence showing prolonged-infusion beta-lactams reduce mortality (RR 0.91, 95% CI 0.85–0.97) and improve clinical cure (RR 1.11, 95% CI 1.06–1.17) in severely ill adults, supported by Bayesian analyses.
Reported
Mortality risk ratio0.91
Mortality 95% confidence interval0.85 to 0.97
Mortality Bayesian posterior prob…98.76%