AUG 18, 2026 · JOURNAL ARTICLE
Integrating metabolism and immunity: targeting lactate-mediated mechanisms in PDAC
Cancer & Metabolism
Mechanistic study in cell and mouse models identifying a novel lactate-TRMT6-SIRT5 pathway in PDAC; no human trials, clinical efficacy not demonstrated, and findings require translational confirmation.
Study details
DesignPreclinical mechanistic study combining in…
InterventionLactate exposure (in vitro); CDK4/6 inhibit…
ComparatorUntreated or standard single-agent controls…