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A sound comparative immunogenicity study in a vulnerable population showing equivalent responses between two widely used vaccines, but limited by cross-sectional design, surrogate endpoints, and lack of clinical outcome data.
This is a narrative review synthesizing structure-guided protein engineering strategies and preclinical immunogenicity data, raising mechanistic questions about pre-F stabilization rather than reporting a definitive clinical or confirmatory experimental result.
A mechanistic study using genetically modified mouse models demonstrating that T cell-associated immunity from a heterologous rBCG/protein vaccine confers cross-variant protection against SARS-CoV-2 JN.1, with clear immunological endpoints but limited to preclinical animal models.