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Brian Fuehrlein

Yale University

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SEP 4, 2026 · JOURNAL ARTICLE

Glucagon-like Peptide-1 Receptor Agonists for Substance Use Disorders: Comprehensive Review of Circuit Mechanisms and Clinical Evidence

Addiction & Prevention

A comprehensive narrative review synthesizing preclinical mechanisms and clinical evidence (pharmacoepidemiologic data plus one RCT) showing GLP-1 RAs may be efficacious for alcohol use disorder with comorbid obesity, but with limited and heterogeneous data across other SUDs and unresolved safety and dosing questions.

PromisingBrian Fuehrlein Diabetes Treatment and Management Adela-Georgiana Buciuc

Study details

DesignNarrative review integrating preclinical me…

InterventionGlucagon-like peptide-1 receptor agonists (…

ComparatorComparators vary by study type; not specifi…

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