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Xiaoping Wang

Beijing University of Chinese Medicine

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AUG 12, 2026 · JOURNAL ARTICLE

Natural ERRα Activator Formononetin Ameliorates Anthracycline Cardiotoxicity via Metabolic Improvement

Circulation Research

Sound mechanistic and preclinical work demonstrating a novel ERRα activator protects against anthracycline cardiotoxicity in animal models with direct target engagement, but lacks clinical trial data in human patients.

PromisingLung Cancer Research Studies Yong Wang Xiaoping Wang

Reported

Study model systemsPorcine, cardiomyocyte-specific transgenic…

Temporal findingERRα reduction at 6-week subclinical stage…

MechanismDirect binding of formononetin to ERRα/PGC-…

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