AUG 13, 2026 · JOURNAL ARTICLE
Menopausal Estrogen Therapy and Risk of Breast Cancer
Obstetrics and Gynecology
Meta-analysis of 10 RCTs in 14,282 participants showing estrogen-only therapy reduces breast cancer risk (RR 0.77, 95% CI 0.65–0.91, P=.002), supported by a large matched cohort in BRCA carriers; rigorous design with clear effect but requires hysterectomy and needs confirmatory data in that specific population.
Reported
Breast cancer incidence (estrogen…3.6%
Breast cancer incidence (placebo…4.7%
Relative risk0.77