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Alessandra Fiore

University of Verona

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JUL 23, 2026 · JOURNAL ARTICLE

Metabolic plasticity underlies ferroptosis resistance driven by mutant p53 in pancreatic ductal adenocarcinoma

Molecular Cancer

Mechanistic study in cell and animal models demonstrating mutant p53-driven ferroptosis resistance and a potential combination therapeutic approach, but lacks clinical trial data and hard patient outcomes.

PromisingAlessandra Fiore Yushu Hu Tian Wang

Study details

DesignPreclinical mechanistic study combining iso…

InterventionFerroptosis inducers; pharmacological react…

ComparatorTP53-knockout cells versus mutant TP53-expr…

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