AUG 8, 2026 · JOURNAL ARTICLE
Type 2 Diabetes in Heart Failure with Preserved and Mildly-Reduced Ejection Fraction: Insights from the REDUCE-LAP-HF II trial
Esc Heart Failure
Rigorous secondary analysis of a prospectively phenotyped cohort with invasive hemodynamic assessment, multivariable adjustment, and hard clinical endpoints over 4-year follow-up demonstrates T2DM's independent association with adverse cardiac remodeling and clinical outcomes in HFpEF/HFmrEF.
Reported
T2DM prevalence37%
Adjusted hazard ratio for HF even…1.96
95% CI for adjusted HR1.28-3.00