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Researcher

Hannah E. Dobson

University of Michigan

1 development in the corpus

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AUG 10, 2026 · JOURNAL ARTICLE

Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy

Nature Nanotechnology

A mechanistic study with in vitro screening and murine tumour models showing enhanced anti-tumour efficacy in combination with anti-PD-1, but no clinical data or human trials reported.

PromisingYoung Seok Cho Hannah E. Dobson Xingwu Zhou

Reported

Compound identified3,4-dihydroxybenzoic acid

Target cell populationCD8+ T cells

Mechanism: glycolysis suppression…Akt-mTORC1-Myc pathway regulation

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