JUL 27, 2026 · JOURNAL ARTICLE
Bioactive molecule-derived covalent organic frameworks as biocompatible scaffolds for targeted AKR1B10 inhibition in alcoholic liver disease.
Biomaterials
This is a preclinical study combining transcriptomic analysis, virtual screening, and chemical synthesis followed by testing in animal models, raising mechanistic questions about AKR1B10 and COF scaffolds rather than establishing clinical efficacy.
Reported
ALD patient cohort size33
Healthy control cohort size23
Number of inhibitors identified4