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Friederike Pijahn

Goethe University Frankfurt

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AUG 12, 2026 · JOURNAL ARTICLE

Fatal pulmonary thromboembolism associated with excessive nitrous oxide consumption over several weeks

International Journal of Legal Medicine

A single fatal case report proposing a mechanistic link between excessive nitrous oxide use, vitamin B12 deficiency, hyperhomocysteinemia, and pulmonary thromboembolism; raises a question rather than establishing causation.

Hypothesis-GeneratingSilvana Petzel‐Witt Friederike Pijahn Stefanie Plenzig

Reported

Ageearly twenties

Duration of excessive nitrous oxi…approximately two months

Nitrous oxide cartridges found at…twenty empty cartridges

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