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Cassandra L. Chapman

University of Otago

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JUL 13, 2026 · JOURNAL ARTICLE

Dual inhibition of respiratory complexes in Mycobacterium tuberculosis results in bacterial killing

Microbiology Spectrum

CRISPR interference study identifying synthetic lethal interactions in mycobacterial respiratory complexes; mechanistic, uncontrolled, and does not yet demonstrate drug efficacy or clinical relevance.

Hypothesis-GeneratingGregory M. Cook Cassandra L. Chapman Matthew B. McNeil

Study details

DesignUncontrolled mechanistic study using CRISPR…

InterventionCRISPRi-mediated transcriptional knockdown…

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