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Mehmet Acun

University of Health Sciences

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AUG 15, 2026 · JOURNAL ARTICLE

The Prognostic Significance of the NOLUS Score in Patients with Metastatic Breast Cancer Receiving CDK 4/6 Inhibitor Therapy

Acta Medica Alanya

Single-center retrospective study of 76 patients testing a novel biomarker score (NOLUS) that failed to show prognostic significance; generates null findings on the primary hypothesis and real-world comparative data but lacks the rigor and external validation needed for clinical recommendation.

PreliminaryEce Ulukal Karancı Mehmet Acun Mustafa Özgür Arıcı

Reported

Sample size76

Median follow-up38.4 months

Median PFS (low-NOLUS)36.6 months

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