AUG 14, 2026 · JOURNAL ARTICLE
DHODH inhibition drives albumin-mediated drug resistance through TERF2IP lactylation-activated macropinosome-mitochondria contact
Nature Communications
This is a mechanistic discovery study identifying a previously unknown metabolic pathway in cell culture and animal models, proposing a novel resistance mechanism rather than testing a clinical intervention or providing evidence for practice change.
Study details
DesignMechanistic discovery study combining CRISP…
InterventionDHODH inhibition (small-molecule inhibitor)…
ComparatorDHODH inhibition alone versus combination w…