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Esmail M. El‐Fakharany

City of Scientific Research and Technological Applications

1 development in the corpus

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SEP 9, 2026 · JOURNAL ARTICLE

Synthesis and in silico studies of hexahydroacridine derivatives as potential antitumor agents

Scientific Reports

Early-stage in vitro screening of novel synthetic compounds with in silico validation; no in vivo efficacy, pharmacokinetics, or toxicology data reported; single lead compound identified but requires substantial further development.

PreliminaryEman A. E. El‐Helw Esmail M. El‐Fakharany Sherif F. Hammad

Reported

IC₅₀ (H460 lung cancer cells)17.91 ± 2.8 µg/mL

Selectivity index (4d vs HSF norm…20.7

TOP2B binding affinity (4d)−7.02 kcal/mol

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