Drug or technology

Animal Testing and Alternatives

2 developments in the corpus

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SEP 1, 2026 · JOURNAL ARTICLE

The Rise of Regulatogens: A Crisis of Insouciance and Dilettantism in the Regulatory DART World—And How We Must Fix It

Birth Defects Research

A critical opinion piece raising concerns about regulatory decision-making in DART testing, without empirical evidence of misclassification rates, outcomes, or systematic analysis to support the claims of crisis.

Hypothesis-GeneratingAnimal Testing and Alternatives John M. DeSesso

AUG 13, 2026 · JOURNAL ARTICLE

Repeated exposure of bumblebee workers to field-realistic doses of di-2-ethylhexyl and di-n-butyl phthalates lowers worker survival and induces obesity-related phenotypes in workers and brood

Ecotoxicology and Environmental Safety

A controlled experimental study showing clear dose-response effects on survival and metabolic endpoints in a relevant model organism, but limited by single species, lab conditions, and absence of field validation or mechanistic confirmation.

PromisingAnimal Testing and Alternatives Sebastien Duterne Laetitia Verdy

Reported

Worker mortality increase with DE…up to 50%

Exposure duration35 days

Exposure frequencyonce per week