JUN 24, 2026 · JOURNAL ARTICLE
Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.
Gut Microbes
Mechanistic mouse model study demonstrating microbiome-mediated tryptophan metabolism disruption correlates with behavioral changes, but lacks human validation, quantified effect sizes, and comparative statistics necessary for clinical translation.
Study details
DesignPreclinical mechanistic study with controll…
InterventionMuc2−/− mice with chronic colitis; germ-fre…
ComparatorMuc2+/+ wild-type mice; specific pathogen-f…