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Xin-Ya Gu

National Yang Ming Chiao Tung University

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JUL 15, 2026 · JOURNAL ARTICLE

Endolysosomal two-pore channels regulate a conserved entry pathway for enteroviruses

Journal of General Virology

A mechanistic study identifying host factors and a potential drug target for enterovirus infection using cell-based assays and knockout models, with broad-spectrum activity but lacking in vivo efficacy or clinical outcome data.

PromisingXin-Ya Gu Ta-Chou Weng Hsu-Hung Cheng

Study details

DesignIn vitro mechanistic study with CRISPR/Cas9…

InterventionCRISPR/Cas9 knockout of TPC1 or TPC2, or ph…

ComparatorWild-type or control-treated cells

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