SEP 4, 2026 · JOURNAL ARTICLE
TCF4 at the crest of development: a zebrafish model to explore craniofacial and gastrointestinal defects in Pitt-Hopkins syndrome
Frontiers in Cell and Developmental Biology
A mechanistic study using a novel animal model to elucidate developmental pathways in a rare disorder; generates testable hypotheses about TCF4 function but does not provide clinical evidence or human validation.
Study details
DesignZebrafish genetic model with functional cha…
InterventionHeterozygous tcf4 mutation via CRISPR/Cas9;…
ComparatorWild-type or heterozygous mutant controls;…