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Luca Titi

Policlinico Umberto I

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SEP 7, 2026 · REVIEW

Sparing Muscle While Losing Fat: A Narrative Review of Ketogenic Diets and Lean Mass Preservation During Weight Loss

Nutrients

A narrative review synthesizing existing clinical evidence on ketogenic diets and lean mass preservation, confirming that protein intake and resistance exercise—not ketosis itself—are the primary determinants of muscle preservation during weight loss.

Important Confirmatory EvidenceFrancesco de Leva Luca Titi Alfredo Caturano

Study details

DesignNarrative review

InterventionKetogenic diet regimens, including supervis…

ComparatorNon-ketogenic weight-loss regimens

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