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Xingchi Jiang

Dalian Medical University

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SEP 3, 2026 · JOURNAL ARTICLE

Integrated Transcriptomics and Lipidomics Identify CES1-Mediated Maladaptive Lipolysis as a Key Target of Hyperlipidemic Acute Pancreatitis

Metabolites

Mechanistic discovery study combining transcriptomics, lipidomics, and a validated mouse model showing proof-of-mechanism for CES1 inhibition in hyperlipidemic acute pancreatitis, but limited to preclinical validation without human efficacy data.

PromisingYunshu Zhang Xingchi Jiang Peiyuan Yin

Reported

Diagnostic accuracy of three-gene…excellent

CES1 correlation with neutrophil…strong

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