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Yu Usami

Department of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.

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JUL 4, 2026 · JOURNAL ARTICLE

CXCL12-abundant reticular cell lineage is the key source of endosteal osteoblasts and adipocytes in adult bone marrow.

Regenerative Therapy

This is a mechanistic lineage-tracing study in genetically modified mice that identifies CAR cells as a source of endosteal osteoblasts and adipocytes, but lacks clinical outcome data, human validation, or therapeutic intervention testing needed to guide practice.

Hypothesis-GeneratingSatoru Toyosawa Yu Usami Leptin Receptor

Reported

Contribution to endosteal osteobl…over 60%

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