APR 30, 2026 · JOURNAL ARTICLE
Effect of intensive versus standard blood pressure control on cardiovascular outcomes: a meta-analysis of randomized controlled trials.
Annals of Medicine
Large meta-analysis of 31 RCTs with 156,933 participants demonstrates consistent, statistically significant reductions across multiple cardiovascular endpoints with narrow confidence intervals; evidence quality limited by heterogeneity across trials and absence of reported adverse event data.
Reported
Sample size156933
Follow-up duration range1.8 to 19.3 years
Major cardiovascular events RR0.80