SEP 10, 2026 · JOURNAL ARTICLE
Guanidinium-rich cell-penetrating peptidomimetic–doxorubicin conjugates show linker-dependent, reduced acute toxicity to cardiomyocytes and normal breast epithelium while retaining activity against a HER2-positive breast cancer model (SKBR3 spheroids)
Frontiers in Chemistry
A sound single-centre in vitro study showing a real conjugate chemistry result—reduced cardiomyocyte toxicity with retained HER2+ cancer activity—but limited to spheroid models, surrogate endpoints, and acute exposure without clinical translation or mechanistic validation.
Reported
SKBR3 IC₅₀ (72 h)<0.5 µM
AC16 (cardiomyocyte) IC₅₀ for fre…<0.5 µM
HB2 (normal epithelium) IC₅₀ for…0.78 µM