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Dimitris Mavridis

University of Ioannina

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JUL 15, 2026 · JOURNAL ARTICLE

A NETwork meta-analysis with COST-effectiveness evaluation of pharmacological treatments for heart failure with reduced ejection fraction: NET-COST-HFrEF

European Journal of Heart Failure

Network meta-analysis of 47 RCTs with 75,978 patients synthesizing efficacy and cost-effectiveness data across multiple healthcare systems, demonstrating quadruple therapy as superior strategy with quantified health economic outcomes.

Strong EvidenceDimitris Mavridis Benedikt N. Beer Gianluigi Savarese

Reported

Sample size75978

Number of RCTs47

Quality-adjusted life-years (quad…12.31

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