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Researcher

Wolfram Brune

Leibniz Institute of Virology (LIV), Hamburg, Germany.

1 development in the corpus

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AUG 26, 2026 · JOURNAL ARTICLE

Molecular cloning of a monkeypox virus clade IIb genome and construction of an attenuated mutant for basic and translational research.

Emerging Microbes & Infections

Early-phase development of a laboratory tool (attenuated viral mutant) with demonstrated feasibility in cell culture and a mouse model, but lacking clinical validation or regulatory approval.

PreliminaryWolfram Brune Christian Meyer Zu Natrup Vincent Klatt

Study details

DesignMolecular cloning and controlled in vitro a…

InterventionThymidine kinase-deficient MPXV mutant (TK-…

ComparatorWild-type MPXV clade IIb (in cell culture a…

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