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Researcher

Yujie Sheng

Ministry of Agriculture and Rural Affairs

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JUL 17, 2026 · JOURNAL ARTICLE

SH3PXD2B is the critical host factor promoting the entry of mycobacteria

Applied and Environmental Microbiology

In vitro mechanistic study identifying a host factor and its role in mycobacterial entry; lacks in vivo validation, clinical outcomes, or human relevance needed to inform practice.

Hypothesis-GeneratingYujie Sheng Xiang Chen Macrophage Migration Inhibitory Factor

Study details

DesignIn vitro genome-wide CRISPR-KO screening wi…

InterventionGenetic depletion of host factors via CRISP…

ComparatorBomac cells without SH3PXD2B knockout or wi…

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