Giredestrant

AUG 17, 2026 · PHASE 3 TRIAL

A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer)

ClinicalTrials.gov

This is a Phase 3 trial registration with no results posted; the study is active but not recruiting, and primary outcome data are not yet available in this registry record.

AUG 17, 2026 · PHASE 3 TRIAL

A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)

ClinicalTrials.gov

This is a Phase 3 trial registration with no results posted; the study is actively recruiting and primary outcomes have not yet been assessed.

AUG 10, 2026 · PHASE 1/2 TRIAL

A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

ClinicalTrials.gov

This is a Phase 1b/2 trial registration with no results posted; the study is actively recruiting and designed to evaluate safety and efficacy of a novel agent in combination therapy for ER+/HER2− breast cancer.