npj Precision Oncology

OCT 16, 2026 · JOURNAL ARTICLE

Machine learning uncovers previously undetectable genetic deletions in cancer panel sequencing

npj Precision Oncology

Abstract Missed genetic deletions can prevent cancer patients from receiving effective targeted therapy. Standard pipelines, such as TSO500, use bin count averaging for copy number

OCT 14, 2026 · JOURNAL ARTICLE

Network analysis and machine learning approach identifies HSP90-associated synthetic lethal targets and drug responses in breast cancer

npj Precision Oncology

Heat shock protein 90 (HSP90) is an ATP-dependent molecular chaperone that stabilizes numerous oncogenic proteins involved in proliferation, survival, DNA repair, and therapeutic r

OCT 12, 2026 · JOURNAL ARTICLE

Multi-omics integration constructs an inflammation-senescence signature for predicting bladder cancer progression and therapy response

npj Precision Oncology

Bladder cancer (BLCA) is a highly heterogeneous malignancy with significant variability in clinical outcomes. The interplay between inflammation and cellular senescence, referred t

OCT 10, 2026 · JOURNAL ARTICLE

Epithelial–mesenchymal transition in immune escape and immunotherapy resistance of lung cancer

npj Precision Oncology

Abstract Epithelial–mesenchymal transition (EMT) drives immunotherapy resistance in lung cancer through three interconnected axes: antigen/checkpoint dysregulation, chemokine remod

SEP 25, 2026 · JOURNAL ARTICLE

Decoding spatial mTOR signalling reveals distinct roles in the tumour microenvironment

npj Precision Oncology

Abstract The tumour microenvironment comprises a variety of cell types that interact with malignant cells, influencing both cancer progression and the patient response to therapy.

SEP 23, 2026 · JOURNAL ARTICLE

Patient-derived vascularized organoid-on-a-chip model for therapeutic response assessment in synovial sarcoma

npj Precision Oncology

Synovial sarcoma (SS) lacks effective therapies and physiologically relevant models that faithfully recapitulate the tumor microenvironment. Here, we established synovial sarcoma p

SEP 22, 2026 · JOURNAL ARTICLE

Prediction of site-specific recurrence and overall survival for colorectal cancer with liver metastases

npj Precision Oncology

Up to 70% of patients with colorectal cancer liver metastases (CRLM) experience recurrence after curative-intent hepatectomy, yet recurrence patterns are heterogeneous across anato

SEP 19, 2026 · JOURNAL ARTICLE

Transarterial infusion chemotherapy and embolization as a novel neoadjuvant therapy for locally advanced gastric cancer: a prospective single-arm pilot study

npj Precision Oncology

Currently, there is limited evidence for the application of interventional therapy in the treatment of hollow viscera tumors. This prospective, single-arm, pilot study (NCT05396326