npj Precision Oncology

SEP 5, 2026 · JOURNAL ARTICLE

Proteogenomic profiling defines progression-associated biology in high-risk endometrial cancer

npj Precision Oncology

A well-designed retrospective proteogenomic study with independent validation cohort showing that proteomic profiling improves risk stratification beyond clinical-genomic classifiers in high-risk endometrial cancer, but limited by single-center design, archival tissue, and lack of prospective validation or intervention outcome data.

AUG 14, 2026 · JOURNAL ARTICLE

Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone

npj Precision Oncology

A sound translational study using ex vivo patient tumors and Phase 1 clinical data to identify immune contexture—not antigen density—as a predictor of TCB response; clinically relevant but exploratory and not yet definitive for practice change.

AUG 14, 2026 · JOURNAL ARTICLE

Single-cell and spatial transcriptomics define the LAMC2+ malignant subtype orchestrating vasculogenic mimicry-mediated resistance in head and neck cancer

npj Precision Oncology

Mechanistic study using transcriptomics and experimental models to propose a resistance pathway; lacks clinical trial evidence or outcome validation of the proposed therapeutic strategy.