Translational Psychiatry

SEP 4, 2026 · JOURNAL ARTICLE

Data-driven dissection of heterogeneity: a computational framework for identifying depression subtypes through multi-omics and explainable AI

Translational Psychiatry

This is a methodological framework paper proposing computational standards for depression subtyping; it does not report empirical trial results, effect sizes, or clinical validation data to support practice change.

AUG 26, 2026 · JOURNAL ARTICLE

Exploring serum biomarkers in paediatric psychiatry: the impact of NfL and GFAP

Translational Psychiatry

A well-designed cross-sectional and longitudinal study of biomarkers in a substantial adolescent psychiatric cohort with clear measurement and modest discriminatory power, but limited by single-centre design, surrogate endpoints, and lack of clinical outcome validation.

AUG 10, 2026 · JOURNAL ARTICLE

The gut microbiota dietary index reveals a modifiable diet–depression association varying by BMI and possibly linked to inflammation: a hypothesis-generating modified diet for future intervention research

Translational Psychiatry

Cross-sectional analysis generating a conceptual framework for future intervention; no causal inference possible, no randomized comparison, and findings explicitly framed as hypothesis-generating rather than definitive.

AUG 4, 2026 · JOURNAL ARTICLE

Predictive dysfunction: toward a unifying mechanism-based framework for psychiatry

Translational Psychiatry

A theoretical framework proposing computational mechanisms underlying psychiatric disorders, without empirical validation data, clinical trials, or mechanistic evidence presented in the source.

AUG 1, 2026 · JOURNAL ARTICLE

Frequency of therapeutic drug monitoring in inpatient precision depression care and duration of hospitalization

Translational Psychiatry

Retrospective observational study showing association between therapeutic drug monitoring frequency and reduced hospitalization duration with cost savings, but lacks randomization, prospective design, and external validation.

JUL 16, 2026 · JOURNAL ARTICLE

Gamma and beta power and the 1/f slope vary across a spectrum of depression severity

Translational Psychiatry

A well-designed cross-sectional study demonstrating graded dose–response relationships between EEG biomarkers and depression severity across a continuous spectrum, but limited by lack of prospective validation, treatment outcome data, or clinical utility thresholds.

JUL 10, 2026 · JOURNAL ARTICLE

Phenotyping antidepressant treatment response with deep learning in electronic health records

Translational Psychiatry

A single-centre, real-world validation study of machine-learning phenotyping using surrogate (note-based) classification of treatment response, without comparison to gold-standard clinical outcomes or prospective clinical utility demonstration.