Science Translational Medicine

OCT 14, 2026 · JOURNAL ARTICLE

Restoration of PP2A AαB56αC trimer formation by RPT04402 molecular glue in high-grade uterine cancer

Science Translational Medicine

The incidence and mortality of high-grade endometrial cancers are increasing, and heterozygous hotspot mutations in PPP2R1A are drivers of the most aggressive forms of uterine canc

SEP 23, 2026 · JOURNAL ARTICLE

SCRMP-mediated SUMOylation of CSNK2B facilitates DNA damage repair to promote cisplatin resistance in small cell lung cancer

Science Translational Medicine

Small cell lung cancer (SCLC) represents the most lethal subtype of lung carcinoma. Platinum-based agents, such as cisplatin and carboplatin, remain the cornerstone of first-line t

SEP 23, 2026 · JOURNAL ARTICLE

CXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis

Science Translational Medicine

Leptomeningeal metastasis (LM) is a fatal neurological complication of cancer. Proton craniospinal irradiation (pCSI) has emerged as a promising life-prolonging intervention for pa

SEP 2, 2026 · JOURNAL ARTICLE

Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells

Science Translational Medicine

A single-centre, mechanistic study identifying a gene target for β-cell transdifferentiation with proof-of-concept in primary human cells and mouse transplantation, but lacking human clinical data and requiring confirmation in larger systems.