Pharmacological Research

OCT 24, 2026 · JOURNAL ARTICLE

GABARAPL1 drives therapeutic differentiation of cancer cells by targeting epigenetic changes regulated by SFPQ

Pharmacological Research

Differentiation-based cancer therapy is a potentially low-toxicity approach with demonstrated clinical benefits. However, the therapeutic efficacy of differentiation therapy remain

SEP 17, 2026 · JOURNAL ARTICLE

Pharmacological intersections between type 2 diabetes and cancer: Metabolic crosstalk, antidiabetic therapies and clinical implications

Pharmacological Research

Type 2 diabetes (T2D) and cancer frequently coexist and are connected by hyperinsulinemia, hyperglycemia, obesity, chronic inflammation, and multiorgan metabolic dysfunction. These

SEP 11, 2026 · JOURNAL ARTICLE

GPR75: A dual-ligand receptor for 20-HETE and CCL5 with emerging roles in central and peripheral regulation of metabolic diseases

Pharmacological Research

G protein-coupled receptor 75 (GPR75) has recently attracted considerable attention as a novel regulator of metabolic, immune, and vascular processes. Current evidence suggests tha

AUG 14, 2026 · JOURNAL ARTICLE

GSDME mediated pyroptosis drives CCL5 secretion and dictates proteasome inhibitor efficacy in solid tumors

Pharmacological Research

Mechanistic study identifying GSDME-mediated pyroptosis as a determinant of proteasome inhibitor efficacy, supported by multiple tumor models and human correlative data, but lacks prospective clinical trials or hard clinical outcomes.