Pharmaceutics

SEP 8, 2026 · JOURNAL ARTICLE

Study on Echinacoside-Copper Metal–Phenolic Networks Hydrogel System Loaded with Diallyl Trisulfide for Local Treatment of Cervical Cancer

Pharmaceutics

A single-center preclinical efficacy study in an orthotopic mouse model with promising tumor inhibition but no human data, safety data limited to histology, and mechanism demonstrated only in cell culture.

SEP 7, 2026 · JOURNAL ARTICLE

Repurposing Niflumic Acid-Loaded PEGylated Cerosomes for Topical Solid Ehrlich’s Carcinoma Management via EGFR/ERK/miR-21 Signaling Pathway Modulation

Pharmaceutics

First-in-concept preclinical study in a murine xenograft model using a novel nanoformulation; lacks human data, comparator arm, and hard clinical outcomes to support practice change.

SEP 4, 2026 · JOURNAL ARTICLE

A Locally Injectable, pH/ROS-Responsive Hydrogel Platform for Combination Therapy of Cervical Cancer with Anti-Fibrotic and Chemotherapeutic Agents

Pharmaceutics

Early-stage preclinical work demonstrating proof-of-concept in cell culture and mouse models; no clinical efficacy data, human trials, or comparison to standard cervical cancer therapy reported.

AUG 30, 2026 · JOURNAL ARTICLE

Recent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles

Pharmaceutics

This is a narrative review summarizing the state of non-viral gene delivery platforms, their clinical maturity, barriers, and future directions for researchers and clinicians.

AUG 14, 2026 · JOURNAL ARTICLE

A Preliminary Evaluation of 177Lu-PSMA-617-Based Targeted Radioligand Therapy with X-Ray Stimulated PSMA Relocation Using the PiggyBac Reporter-Gene-Engineered Orthotopic Prostate Tumor Model

Pharmaceutics

Early-phase preclinical study in engineered xenograft models evaluating a novel combination approach; no clinical efficacy data, surrogate endpoints only, and single-arm treatment groups without formal statistical comparison.

AUG 14, 2026 · JOURNAL ARTICLE

Bergapten as a Multifunctional Phytochemical in Cancer Therapy: Mechanistic Insights, Pharmacokinetics, and Possible Nanotechnology-Enabled Formulation Strategies

Pharmaceutics

This is a mechanistic review of preclinical evidence for bergapten in cancer, synthesizing in vitro and animal studies without human clinical data or efficacy trials to support therapeutic translation.

AUG 11, 2026 · JOURNAL ARTICLE

Novel BODIPY-Loaded Liposomes Enhance Cellular Uptake and PDT Efficacy in 2D and 3D Models

Pharmaceutics

In vitro proof-of-concept study of a novel liposomal formulation in cancer cell lines and spheroids, demonstrating mechanism but lacking in vivo efficacy data, pharmacokinetics, or clinical readiness.

AUG 7, 2026 · JOURNAL ARTICLE

The Right Key, the Wrong Lock: TIGIT Checkpoint Blockade and the Road to Precision Immunotherapy

Pharmaceutics

A narrative review synthesizing preclinical rationale and failed clinical trials to propose mechanistic explanations and future directions, without new empirical data or definitive evidence on efficacy.