PLOS One

SEP 9, 2026 · JOURNAL ARTICLE

A Latent profile and network intervention analysis of psychosomatic symptoms in lung cancer immunotherapy patients

PLOS One

Cross-sectional observational study identifying symptom phenotypes and generating hypotheses about intervention targets through network analysis and computer simulation, without intervention trials or prospective validation.

SEP 9, 2026 · JOURNAL ARTICLE

Prevalence of high-risk human papillomavirus genotypes and associated factors among HIV-infected women in a reproductive age group attending antiretroviral therapy in Nekemte town, Oromia, Ethiopia

PLOS One

Single-centre cross-sectional study of prevalence and associated factors in a specific population; provides descriptive findings without a control group or intervention, suitable for hypothesis generation and local planning but requiring confirmation in broader populations.

AUG 14, 2026 · JOURNAL ARTICLE

Good DNA- and sufficient RNA integrity in formalin-free paraffin-embedded tissues

PLOS One

A sound experimental comparison of a novel tissue-embedding technique showing superior DNA integrity and adequate RNA quality for molecular diagnostics, but limited by single-centre design, lack of clinical outcome data, and incomplete characterization of long-term stability.

AUG 13, 2026 · JOURNAL ARTICLE

Caregiver burden and its association with depression, anxiety, and quality of life among caregivers of individuals with severe persistent mental illness in Saudi Arabia: A cross-sectional study

PLOS One

A cross-sectional study of moderate sample size from a single centre reporting statistically significant correlations between caregiver burden and mental health outcomes, but lacking a comparator group and relying on self-reported questionnaires, limiting causal inference.

AUG 13, 2026 · JOURNAL ARTICLE

Shedding light on neural learning to rank models for anticancer drug prioritization

PLOS One

This is a benchmarking and methods development study using machine learning on existing drug-screening datasets with no prospective validation, clinical outcomes, or independent test cohort, demonstrating feasibility and interpretability of neural ranking models rather than efficacy.

AUG 13, 2026 · JOURNAL ARTICLE

Scalp cooling versus standard cold-cap in preventing chemotherapy-induced alopecia in patients with localized breast cancer: ICELAND protocol, a randomized controlled trial and economic evaluation

PLOS One

This is a protocol paper describing a planned phase III RCT; no results are reported, only study design and endpoints.

AUG 11, 2026 · JOURNAL ARTICLE

A report on the mechanisms of sweeteners in four musculoskeletal disorders: Insights from network toxicology, molecular docking, and molecular dynamics simulations

PLOS One

Computational modelling study with no experimental validation, clinical data, or human evidence; raises mechanistic questions about sweetener effects on musculoskeletal health but does not answer them.

JUL 31, 2026 · JOURNAL ARTICLE

Global, Regional, and National Burden of chronic kidney disease in older adults from 1990 to 2021: Results from the Global Burden of Disease Study 2021

PLOS One

Large-scale epidemiological analysis of established disease burden using rigorous GBD methodology, confirming and extending known patterns of CKD prevalence and mortality in older adults, but not introducing novel interventions or practice changes.