PLOS Computational Biology

OCT 21, 2026 · JOURNAL ARTICLE

SADRP: A structurally aware multi-modal framework for drug response prediction

PLOS Computational Biology

Motivation Predicting drug sensitivity across diverse cancer samples is a fundamental challenge in personalized therapy and drug discovery. This task requires comprehensive charact

OCT 12, 2026 · JOURNAL ARTICLE

Understanding cell fate decisions with temporal attention

PLOS Computational Biology

Understanding non-genetic determinants of cell fate is critical for developing and improving cancer therapies, as genetically identical cells can exhibit divergent outcomes under t

SEP 18, 2026 · JOURNAL ARTICLE

Evolutionary rescue model informs strategies for driving cancer cell populations to extinction

PLOS Computational Biology

Cancers exhibit a remarkable ability to develop resistance to a range of treatments, often resulting in relapse following first-line therapies and significantly worse outcomes for

SEP 8, 2026 · JOURNAL ARTICLE

Non-coding RNA 7SK drives tumor resistance by coupling local oncogenic activation with global transcriptional repression

PLOS Computational Biology

This is a mechanistic study using computational and functional approaches to characterize a non-coding RNA's role in cancer, raising questions about therapeutic potential rather than testing clinical efficacy or providing definitive evidence of practice-changing utility.