Neuro-oncology Advances

OCT 7, 2026 · JOURNAL ARTICLE

Protective effects of testosterone replacement therapy on brain tumor outcomes: the Mayo Clinic Experience

Neuro-oncology Advances

Abstract Background Biological sex and endocrine signaling influence cancer biology, immune response, and therapeutic outcomes. Recent evidence suggests that testosterone signaling

SEP 10, 2026 · JOURNAL ARTICLE

Macrophage migration inhibitory factor is a potential therapeutic target for cisplatin induced peripheral neuropathy in breast cancer

Neuro-oncology Advances

Mechanistic preclinical study in mouse models proposing MIF as a therapeutic target; lacks clinical validation, hard endpoints, or translation to patient benefit.

AUG 8, 2026 · JOURNAL ARTICLE

Nuclear export inhibition activates TP53 pathways and is a potent therapeutic strategy in atypical teratoid rhabdoid tumors

Neuro-oncology Advances

Sound preclinical study with patient-derived models and in vivo validation showing XPO1 inhibition activates TP53 and reduces tumor burden, but lacks clinical trial data and human efficacy evidence.