Nature

NOV 4, 2026 · JOURNAL ARTICLE

Comprehensive mapping of essential-gene interactions in M. tuberculosis

Nature

Abstract Mycobacterium tuberculosis, the causative agent of tuberculosis, remains the world’s deadliest pathogen 1. Despite intensive study, many of its genes remain uncharacterize

OCT 28, 2026 · JOURNAL ARTICLE

Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers

Nature

Abstract The N7-methylguanosine (m 7 G) modification is one of the most prevalent tRNA modifications, mainly catalysed by the METTL1–WDR4 protein complex 1–4. The m 7 G methyltrans

OCT 28, 2026 · JOURNAL ARTICLE

Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer

Nature

Abstract Dynamic interactions between tumours and their microenvironment are crucial for cancer progression and therapeutic outcomes 1,2. However, our understanding of these relati

OCT 14, 2026 · JOURNAL ARTICLE

Artificial intelligence-enabled clinical phenotyping of human brown fat

Nature

Adipose tissue has a central role in systemic energy balance and the pathogenesis of obesity and its sequelae1,2. In contrast to white adipose tissue, brown adipose tissue (BAT) us

OCT 7, 2026 · JOURNAL ARTICLE

tRNA dosage regulates lineage dependency and resistance in prostate cancer

Nature

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prosta

SEP 23, 2026 · JOURNAL ARTICLE

Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

Nature

CD8+ T cell exhaustion impedes control of chronic viral infection and cancer. This hypofunctional state is characterized by downregulation of the high-affinity IL-2 receptor (IL-2R

SEP 16, 2026 · JOURNAL ARTICLE

Identification of broadly tumour-reactive γδ TCRs from multiple myeloma

Nature

γδ T cells are becoming increasingly appreciated for their antitumour capacity and role in mediating responses to immune checkpoint blockade1–3. Unlike classical αβ T cells, the de

SEP 16, 2026 · JOURNAL ARTICLE

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

Nature

Histological variation is a prognostic feature of metastatic urothelial cancer1–3, but its evolutionary trajectory remains poorly defined. We developed a metastatic bladder cancer