Angiogenesis is a major driver of tumor progression and a validated therapeutic target in highly vascularized cancers such as clear cell renal cell carcinoma. However, the clinical
Transcription factors (TFs) are often considered undruggable due to their structural complexity. mRNA technologies can overcome this therapeutic limitation by enabling dynamic prot
Drug resistance significantly limits the long-term effectiveness of targeted therapies in lung cancer. AXL, a receptor tyrosine kinase (RTK), is a well-established driver of drug r
A systematic review synthesizing evidence on biomarkers for BCG therapy prediction in bladder cancer; provides a landscape assessment rather than a new empirical result, identifying gaps and promising directions for clinical practice.
Observational microbiota profiling study in a single cohort showing modest associations with survival outcomes, lacking a control group and powered only to detect compositional differences, not clinical prediction.
Meta-analysis of public transcriptomic data identifying candidate biomarkers and immune signatures associated with neoadjuvant response in rectal cancer, but without clinical validation, prospective design, or outcome prediction model.