Molecular Medicine

OCT 15, 2026 · JOURNAL ARTICLE

Novel therapeutics for platinum-resistant ovarian cancer: from biological mechanisms to emerging biomarker-guided strategies

Molecular Medicine

For decades, platinum resistance has remained one of the major barriers to improving outcomes in ovarian cancer. Patients with platinum-resistant ovarian cancer (PROC) generally ha

OCT 13, 2026 · JOURNAL ARTICLE

Adipose Cirbp protects against diet-induced obesity by regulating Vav3 to promote brown fat thermogenesis

Molecular Medicine

Brown adipose tissue (BAT) thermogenesis has emerged as a critical therapeutic target for obesity. However, the precise regulatory mechanisms remain incompletely elucidated. Cold-i

OCT 8, 2026 · JOURNAL ARTICLE

Pharmacological GPR39 activation protects against MASLD/MASH and improves metabolic syndrome features: a preclinical study in diet-induced mouse models

Molecular Medicine

Effective therapeutics for metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are urgently needed as their

OCT 7, 2026 · JOURNAL ARTICLE

CD248 expression in human adipose tissue is upregulated in obesity and following glucocorticoid exposure: a mediator of insulin resistance and adipose dysfunction?

Molecular Medicine

Abstract Background CD248 is a transmembrane glycoprotein implicated in fibrosis, hypoxia, and insulin resistance, but its role in human adipose tissue remains incompletely underst

OCT 3, 2026 · JOURNAL ARTICLE

Cyclin/CDK inhibition in cancer therapy: from small molecules and macrocycles to advanced drug delivery systems

Molecular Medicine

Cyclin-CDK complexes have attracted growing interest as therapeutic targets due to their crucial role in cell cycle regulation and their application in cancer treatment. Moreover,

OCT 1, 2026 · JOURNAL ARTICLE

The interplay of cGAS-STING and autophagy: bidirectional regulation and pathophysiological implication

Molecular Medicine

Abstract The cGAS-STING pathway is a fundamental cytosolic DNA-sensing mechanism that activates innate immune responses through the production of type I interferons (IFNs) and othe

SEP 29, 2026 · JOURNAL ARTICLE

The protein kinase IKK epsilon shapes the melanoma tumor microenvironment by modulating angiogenesis and the T-cell immunity

Molecular Medicine

Abstract Background Inhibitor of nuclear factor kappa-B kinase epsilon (IKKε) contributes to tumorigenesis and metastasis in various cancers. In melanoma, it is overexpressed and c

SEP 22, 2026 · JOURNAL ARTICLE

Proteogenomic Analysis of HDAC4 and HDAC5 in Uveal Melanoma

Molecular Medicine

Abstract Uveal melanoma (UM) is a rare but aggressive cancer arising from cells of the uveal tract that is highly resistant to therapy once it has metastasized. In drug screening e