Abstract There is a critical need to identify validated biomarkers that can predict cancer patient outcomes. This study evaluated biomarkers of neutrophil extracellular traps (NETs
Abstract Sirtuins (SIRT1–SIRT7) are evolutionarily conserved NAD + -dependent deacylases that function as metabolic sensors, coupling cellular metabolic state to epigenetic, transc
Abstract Type 1 diabetes mellitus (T1DM) is characterized by the destruction of pancreatic β-cells, in which the dysfunction of regulatory T cells (Tregs) contributes to impaired i
Abstract Chronic colitis is a major risk factor for colorectal cancer (CRC), particularly for colitis-associated colorectal cancer (CAC), where persistent inflammation drives the t
Abstract The role of gut microbiota and their metabolites in the progression of hepatocellular carcinoma (HCC) has garnered increasing attention. Although Alistipes, a genus freque
Abstract The infiltration of tumors by CD8⁺ T lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. However, the presence of tumor-specific CD8
Abstract Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecu
Abstract While dietary therapies targeting individual amino acids in cancer show promise in modulating tumor metabolism, the issue of nutrient competition between tumors and the im