Medicine

SEP 4, 2026 · JOURNAL ARTICLE

Case report

Medicine

A single case report describing clinical response to tirzepatide in an adult with Prader–Willi syndrome and refractory diabetes; lacks comparison group, quantified outcomes, and generalizability.

AUG 14, 2026 · JOURNAL ARTICLE

Epidemiology of ischemic stroke in China and the United States

Medicine

Rigorous population-based retrospective analysis using Global Burden of Disease data with sophisticated temporal trend analysis and projections, providing clear epidemiological comparisons across two major countries, though descriptive rather than causal or interventional.

AUG 14, 2026 · JOURNAL ARTICLE

Lactate dehydrogenase-to-lymphocyte ratio predicts overall and progression-free survival among patients with advanced small-cell lung cancer receiving first-line chemoimmunotherapy

Medicine

A real result from a sound but limited retrospective study showing LLR predicts OS and PFS in advanced SCLC, but small sample size, single disease context, and lack of prospective validation limit immediate clinical application.

AUG 14, 2026 · JOURNAL ARTICLE

Primary gastric plasmacytoma evolving to non-secretory multiple myeloma

Medicine

A single case report documenting an unusual clinical trajectory; provides descriptive evidence of disease evolution but lacks comparative data, control group, or generalizable findings.

AUG 14, 2026 · JOURNAL ARTICLE

Demographic time bomb in COPD (1990–2050)

Medicine

A descriptive epidemiological analysis and modelling study synthesizing historical Global Burden of Disease data with Bayesian projections to 2050; no intervention trial, no novel mechanism, and projections rest on model assumptions not validated against future outcomes.

AUG 14, 2026 · JOURNAL ARTICLE

Postoperative cutaneous metastasis of breast cancer with phenotypic conversion to triple-negative subtype

Medicine

A single case report documenting an unusual clinical phenomenon (phenotypic conversion in breast cancer metastasis) with descriptive pathology and treatment response, insufficient to establish efficacy or guide practice.

AUG 14, 2026 · JOURNAL ARTICLE

Combination of PD-1 inhibitor and chemotherapy for subcutaneous soft-tissue metastasis in postoperative non-small cell lung cancer

Medicine

A single case report with no comparator, control group, or quantified efficacy metrics; describes feasibility and tolerability rather than establishing efficacy through controlled evidence.

AUG 14, 2026 · JOURNAL ARTICLE

Pulmonary sarcomatoid carcinoma in the anterior mediastinum mimicking thymic carcinoma with rapid widespread metastases

Medicine

Single case report with diagnostic and treatment lessons, but no comparative data, controlled intervention, or outcome metrics that permit evidence-grading of efficacy.