Life Science Alliance

NOV 5, 2026 · JOURNAL ARTICLE

A modular lentiviral system for multiplexed gene perturbation and functional analysis suggests interdependence of hormone receptors in breast cancer growth in vivo.

Life Science Alliance

Precise and flexible control of gene expression is essential for dissecting gene function in complex biological systems. Although recent developments in genetic engineering and CRI

NOV 4, 2026 · JOURNAL ARTICLE

Diacylglycerol kinase kappa is a target of the Prader-Willi syndrome gene SNORD116.

Life Science Alliance

SNORD116 is a small nucleolar RNA deficient in Prader-Willi syndrome individuals. The mechanisms by which SNORD116 conveys its effects are unknown. Here, transcriptomic analysis sh

OCT 1, 2026 · JOURNAL ARTICLE

A selective inhibitor reveals roles for LONP1 in mitochondrial proteostasis and OXPHOS dependencies.

Life Science Alliance

Lon protease 1 (LONP1) is a conserved hexameric protease implicated in mitochondrial disorders and cancer progression. In this study, we present PZL-26, a potent and selective smal

SEP 17, 2026 · JOURNAL ARTICLE

Drug-induced metabolic remodeling promotes antimicrobial activity in macrophages and extends longevity in vivo.

Life Science Alliance

Multiple immune mechanisms must be coordinated to defend against a broad range of pathogens; however, the mechanisms by which broad-spectrum antipathogens act remain largely elusiv