Journal of Translational Medicine

SEP 8, 2026 · JOURNAL ARTICLE

CAF-mediated immune exclusion in osteosarcoma: mechanisms, translational vulnerabilities, and therapeutic strategies

Journal of Translational Medicine

This is a narrative review synthesizing mechanistic and preclinical evidence on CAF biology in osteosarcoma, proposing translational directions without clinical trial data or validated biomarkers.

SEP 6, 2026 · JOURNAL ARTICLE

Perineural invasion in hepatocellular carcinoma: clinical evidence and mechanistic hypotheses

Journal of Translational Medicine

A synthesis paper proposing mechanistic hypotheses for perineural invasion in HCC based on limited and inconsistently defined clinical data, without new experimental results or clinical trials to test the proposed mechanisms.

SEP 4, 2026 · JOURNAL ARTICLE

Lipid metabolic reprogramming in NSCLC: mechanisms, microenvironment crosstalk, and therapeutic opportunities

Journal of Translational Medicine

A phase 1 study reporting a preliminary signal of activity in a molecular subtype (KRAS-mutant NSCLC, n=11) with a small sample, surrogate endpoint (progression-free status at 12 weeks), and no established clinical efficacy in unselected patients.

SEP 2, 2026 · JOURNAL ARTICLE

NRF2 activation attenuates obesity-induced adipose inflammation by suppressing STING signaling, with depot-specific regulation

Journal of Translational Medicine

Mechanistically rigorous preclinical study with in vitro and in vivo evidence in mouse models showing NRF2 activation suppresses obesity-related inflammation via STING inhibition, but lacks human data and clinical endpoints needed for stronger evidence grade.

AUG 28, 2026 · JOURNAL ARTICLE

Comprehensive review of myalgic encephalomyelitis/chronic fatigue syndrome

Journal of Translational Medicine

A comprehensive narrative review synthesising epidemiology, pathophysiology, and therapeutic evidence for ME/CFS, offering clinical and research direction rather than reporting original data or a single definitive trial.

AUG 13, 2026 · JOURNAL ARTICLE

Three-dimensional spheroid models in breast cancer: tumor microenvironment complexity, cancer stem cell-driven resistance, and translational model integration

Journal of Translational Medicine

This is a comprehensive narrative review synthesizing existing literature on 3D spheroid models rather than reporting original research data, evidence of efficacy, or definitive clinical outcomes.

AUG 13, 2026 · JOURNAL ARTICLE

Mitochondria as the core regulator of cell death: from classical programmed cell death to the novel mitoxyperiosis pathway

Journal of Translational Medicine

This is a narrative review synthesizing existing knowledge about mitochondrial regulation of cell death and proposing a conceptual framework; it raises questions and integrates evidence rather than presenting new empirical findings or clinical outcomes.

AUG 11, 2026 · JOURNAL ARTICLE

T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors

Journal of Translational Medicine

Phase 1 investigator-initiated trial in 12 patients with heterogeneous solid tumors, showing feasibility and a 33.3% response rate, but underpowered for efficacy claims and mechanistic findings rely on uncontrolled in vitro and in vivo knockout experiments.