Abstract Background Polycystic ovary syndrome (PCOS) is a heterogeneous reproductive and metabolic disorder. Whether gut microbiota-associated metabolites contribute to ovarian dys
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, strongly associated with metabolic dysfunction, particularly insulin resistance. Di
Ovarian cancer (OC) is one of the deadliest malignancies among women and is often diagnosed at advanced stages. Chronic inflammation plays a key role in the initiation and progress
Abstract Paclitaxel (PTX) resistance in epithelial ovarian cancer (EOC) is a significant clinical challenge, often resulting in cross-resistance to other chemotherapeutic agents an
Preclinical discovery study using virtual screening and in vitro/xenograft models without clinical data; identifies a candidate compound but requires clinical validation.
A retrospective, cross-sectional genotyping study proposing a mechanistic pathway (MTHFR genotype → homocysteine → metabolic heterogeneity) without causal evidence; the authors acknowledge exploratory design and explicitly call for prospective validation.
This is a narrative review of emerging fluorescent probe technologies for ovarian cancer diagnosis and surgery, raising mechanistic and translational questions rather than reporting empirical trial results or clinical outcomes.
Mechanistic study in cell lines and xenografts identifying a regulatory pathway; no clinical trial data, and findings require confirmation in human subjects.